Circadian rhythms

Circadian rhythm, our body’s internal clock, plays an important role in Alzheimer’s disease (AD). Follow us to check this connection:

Circadian Rhythms and Alzheimer’s :

• Circadian rhythms describe the physical, mental, and behavioral patterns that follow a 24-hour cycle .
•  Disruption of circadian rhythms is common in people with AD and contributes to:
•  Cognitive decline
• Confusion in the evening
•  Trouble falling andstaying asleep .

 Microglia and Protein Clearance :

•  Microglia are immune cells in the brain that clear up harmful proteins.
•  One such protein is amyloid beta , a hallmark of AD.
•  Researchers found that microglia follow a 24-hour circadian rhythm for protein-clearing.
•  Disruption to this rhythm may lead to accumulation of amyloid beta plaques , which are linked to AD.

 Complex Interplay :

• While sleep disturbances often arise before AD, the relationship is complex.
• Disrupting sleep and circadian rhythms allows amyloid beta buildup.
• In turn, damaged brain cells affect the circadian clock, leading to further amyloid beta accumulation.
• Maintaining good sleep hygiene may help mitigate AD symptoms.

In summary, understanding the link between circadian rhythms and AD offers new avenues for therapies.

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(2) Study finds link between Alzheimer’s and circadian clock. 

(3) The body’s internal clock could help explain an incurable … – Inverse.

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(5) Alzheimer’s and the body clock: A new treatment avenue?.

(6) Alzheimer’s disease linked to circadian rhythm – new research in mice. 

(7) Circadian Rhythm Connections to Alzheimer’s | Psychology Today. 

(8) Circadian clocks, cognition, and Alzheimer’s disease: synaptic ….