Hydrogen therapy in the treatment of Alzheimer’s disease (AD)

Hydrogen therapy has shown promise in the treatment of Alzheimer’s disease (AD) . Let’s delve into the research findings:

1. Background and Mechanism :

– AD is a progressive and fatal neurodegenerative disorder affecting cognition, memory, and behavior.

– Hydrogen gas (H₂) , known for its multiple functions (antioxidant, anti-inflammatory, anti-cell death, and energy metabolism stimulation), was investigated as a potential disease-modifying treatment for AD.

2. Clinical Study :

– An open-label pilot study involved eight AD patients.

– Participants inhaled 3% H₂ gas for one hour twice daily for 6 months and were then followed for 1 year without H₂ inhalation.

– Assessment Tools :

– Alzheimer’s Disease Assessment Scale-cognitive subscale (ADAS-cog) : Used to evaluate cognitive function.

– Diffusion tensor imaging (DTI) with advanced magnetic resonance imaging (MRI): Assessed neuron integrity in bundles passing through the hippocampus.

3. Results :

– After 6 months of H₂ treatment:

– ADAS-cog change : Significant improvement (mean change: -4.1) compared to untreated patients (+2.6).

– DTI assessment : H₂ treatment improved neuron integrity in hippocampal pathways.

– These improvements were maintained during the follow-up after 6 months (significantly) and 1 year (non-significantly).

4. Conclusion :

– H₂ treatment not only provides temporary symptom relief but also exhibits disease-modifying effects for AD, despite limitations.

– Keywords: ADAS-cog, Alzheimer’s disease, diffusion tensor imaging, neuronal integrity, hydrogen gas, disease-modifying treatment¹.

In summary, hydrogen therapy holds promise as a potential avenue for managing Alzheimer’s disease, offering hope for improved cognitive function and neuronal health.

• (1) Therapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients …. 
• (2) New Clinical Trials on Hydrogen Inhalation for Alzheimer’s Disease Show …. 
• (3) Chinese Scientists Pioneer Age-Reversing Hydrogen Therapy, Targets …. 
• (4) Molecular Hydrogen: an Emerging Therapeutic Medical Gas for … – Springer.